Oncology (Cancer) Genetics

ColoTect Non-Invasive Colorectal Cancer Screening

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According to the World Health Organization, Colorectal cancer (CRC) is the third most common cancer type worldwide; in 2020,Almost 2 million cases were diagnosed.

Colorectal cancer is the second most common cause of cancer death, leading to almost 1 million deaths per year. This is even though effective screening techniques exist that could reduce the number of deaths from this disease.

Colorectal cancer (CRC) is the most preventable yet least prevented form of cancer. When caught in early stages, it is more treatable in 90% of people


ColoTect Approach

Convenient – Self-sampling at home with no special preparation needed.

ColoTect is a non-invasive, highly sensitive screening test for colorectal cancer (CRC) and precancerous lesions. Human DNA is extracted from stool sample self-collected at home by the patient and used for multiplex methylation specific PCR to detect abnormally methylated CRC marker genes——SDC2, ADHFE1, and PPP2R5C.

Why Early Screening Matters

The second highest mortality

The third highest incidence

Risk of CRC increases dramatically after the age of 50 years

Screening is an important step in finding early stages of CRC that can be 90% cured when caught early


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Self-sampling at home. No special prep or need for time off

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Highly sensitive to find 87% CRC and 42.1% advanced adenoma

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Specificity is as high as 93%

Who Should Be Screened for Colorectal Cancer?

average-risk adults aged 45 to 75 years

*The NCCN guideline recommends a screening interval of every 3 years with stool DNA test.

American Cancer Society recommends starting regular screening at age 45.


Turnaround times for specific tests vary as per the table below. TATs are calculated from the time the sample is received and accepted at the laboratory.

Genalive offers:

Product Name Product Code TAT
ColoTect Non-invasive Colorectal Cancer Screening SDX2101 5 days

Genalive Genetic Counselors are available to Healthcare providers to help navigate which test is best for their patient.