Preimplantation Genetic Testing for Aneuploidy (PGT-A)
Preimplantation Genetic Testing for Monogenic Disorders (PGT-M)
Clinical Whole Exome Sequencing (cWES)
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Hereditary Cancer Screening
Why to Test Hereditary Cancer?
Individuals with a family history of cancer may have an increased risk of cancer if they have inherited a cancercausing mutation. Different gene mutations can cause diverse types of cancer.
Hereditary cancers account for approximately 5-10% of all cancers, and people who inherit genetic mutations generally are more likely to develop certain cancers at an earlier age of onset than the common population.
With the genetic information, high-risk people can take a regular examination and preventive measures to improve health and quality of life.
Saliva: ≥2ml
peripheral blood: ≥5ml
good quality DNA: ≥3µg
Detects 79 gene across 24 important cancers with complete database
Only 5mL blood or 2mL saliva is needed for testing
99.9% accuracy with alternative validation
Next-generation sequencing for the whole-exome plus flanking intronic regions covered for all genes tested; one single assay that detects point mutations, deletions, insertions, duplications, rearrangements.
For patients
confirm the cause of cancer
guide treatment decisions
assess the risk of other cancers
For healthy people and relatives
assess the risk of hereditary cancers
take necessary interventions for testee and family members
Turnaround times for specific tests vary as per the table below. TATs are calculated from the time the sample is received and accepted at the laboratory.
| Product Name | Product Code | TAT |
|---|---|---|
| Sentis™ BRCA (2 genes) | SDX2001 | 10-15 days |
| Sentis™ Hereditary Breast and Ovarian Cancer (HBOC) (26 genes) | SDX2002 | 10-15 days |
| Sentis™ Hereditary Cancer Panel (Female) (85 genes) | SDX2003 | 10-15 days |
| Sentis™ Hereditary Cancer Panel (Male)(90 genes) | SDX2004 | 10-15 days |
| Sentis™ Hereditary Pancreatic Cancer | SDX2005 | 10-15 days |
| Sentis™ Hereditary Prostate Cancer | SDX2006 | 10-15 days |
| Sentis™ Hereditary Colorectal Cancer | SDX2006 | 10-15 days |
Genalive Genetic Counselors are available to Healthcare providers to help navigate which test is best for their patient.
| Hereditary cancer type | Male package | Female package |
|---|---|---|
| Breast | √ | √ |
| Ovarian | √ | |
| Prostate | √ | |
| Colorectal | √ | √ |
| Melanoma | √ | √ |
| Gastric | √ | √ |
| Endometrial | √ | |
| Renal | √ | √ |
| Pancreatic | √ | √ |
| Bladder | √ | √ |
| Thyroid | √ | √ |
| Parathyroid | √ | √ |
| Multiple Endocrine Neoplasia | √ | √ |
| Neurofibromatosis | √ | √ |
| Pheochromocytoma | √ | √ |
| Familial Paraganglioma | √ | √ |
| Retinoblastoma | √ | √ |
| Chondrosarcoma | √ | √ |
| Gastrointestinal Stromal | √ | √ |
| Urothelial Carcinoma | √ | √ |
| Tuberous Sclerosis | √ | √ |
| Nephroblastoma | √ | √ |
| Neuroblastoma | √ | √ |
| Nevoid Basal Cell Carcinoma | √ | √ |
